Project

# Title Team Members TA Documents Sponsor
33 Autologous Transcranial Implant for the Delivery of Photodynamic Therapy for Intracranial Brain Tumors
 Brian Diner
Jack Stender
Mohamed Belakhoua
 Sarath Saroj design_document1.pdf
final_paper1.pdf
proposal1.pdf
video
# Autologous Transcranial Implant for the Delivery of Photodynamic Therapy for Intracranial Brain Tumors

Team Members:
- Jack Stender (stender3)
- Mohamed Belakhoua (mab21)
- Brian Diner (bdiner2)

# Problem

Glioblastoma has a very poor prognosis of 12-15 months post-operation. The current standard of treatment is surgical resection, radiation therapy, and chemotherapy. There exists one FDA-approved device on the market that attempts to solve a similar problem - Optune. Other alternatives exist as well but they have low efficacy overall. In recent trials, photodynamic therapy has proven effective in treating cancerous cells though currently it can only be administered mid-surgery while the brain is exposed.

# Solution

To allow for photodynamic therapy to be administered post-operatively, we propose developing a small transcranial implant that would provide the light source for this therapy. Our objective is to create a programmable device that can be implanted through the skull which will provide control over PDT delivery chronically, allowing patients with GBM to be photo-irradiated without re-entering the operating room after their resection is completed. Components of this transcranial implant would include the appropriate light source, a light diffuser, battery, and an on/off mechanism.


# Solution Components

## Light Source / Light Diffuser

- Medical grade titanium socket implant attached to the skull.
- Medical grade resin printed LED diffuser sitting in metal socket. Similar size to an apple watch in all dimensions

## Battery

- Single-use battery - taking cues from pacemaker design

## On/off Mechanism

- RFID or bluetooth code transmission to the microcontroller determines when and how LEDs are on

# Criterion For Success

Create a working prototype of a Photodynamic Therapeutic device. Create a custom PCB for an LED diode array that can be remotely programmed for the duration and intensity of the light. Design and implement a 3D-printed casing in the dimensions of the final product.

Electronic Replacement for COVID-19 Building Monitors @ UIUC

Patrick McBrayer, Zewen Rao, Yijie Zhang

Featured Project

Team Members: Patrick McBrayer, Yijie Zhang, Zewen Rao

Problem Statement:

Students who volunteer to monitor buildings at UIUC are at increased risk of contracting COVID-19 itself, and passing it on to others before they are aware of the infection. Due to this, I propose a project that would create a technological solution to this issue using physical 2-factor authentication through the “airlock” style doorways we have at ECEB and across campus.

Solution Overview:

As we do not have access to the backend of the Safer Illinois application, or the ability to use campus buildings as a workspace for our project, we will be designing a proof of concept 2FA system for UIUC building access. Our solution would be composed of two main subsystems, one that allows initial entry into the “airlock” portion of the building using a scannable QR code, and the other that detects the number of people that entered the space, to determine whether or not the user will be granted access to the interior of the building.

Solution Components:

Subsystem #1: Initial Detection of Building Access

- QR/barcode scanner capable of reading the code presented by the user, that tells the system whether that person has been granted or denied building access. (An example of this type of sensor: (https://www.amazon.com/Barcode-Reading-Scanner-Electronic-Connector/dp/B082B8SVB2/ref=sr_1_11?dchild=1&keywords=gm65+scanner&qid=1595651995&sr=8-11)

- QR code generator using C++/Python to support the QR code scanner.

- Microcontroller to receive the information from the QR code reader and decode the information, then decide whether to unlock the door, or keep it shut. (The microcontroller would also need an internal timer, as we plan on encoding a lifespan into the QR code, therefore making them unusable after 4 days).

- LED Light to indicate to the user whether or not access was granted.

- Electronic locking mechanism to open both sets of doors.

Subsystem #2: Airlock Authentication of a Single User

- 2 aligned sensors ( one tx and other is rx) on the bottom of the door that counts the number of people crossing a certain line. (possibly considering two sets of these, so the person could not jump over, or move under the sensors. Most likely having the second set around the middle of the door frame.

- Microcontroller to decode the information provided by the door sensors, and then determine the number of people who have entered the space. Based on this information we can either grant or deny access to the interior building.

- LED Light to indicate to the user if they have been granted access.

- Possibly a speaker at this stage as well, to tell the user the reason they have not been granted access, and letting them know the

incident has been reported if they attempted to let someone into the building.

Criterion of Success:

- Our system generates valid QR codes that can be read by our scanner, and the data encoded such as lifespan of the code and building access is transmitted to the microcontroller.

- Our 2FA detection of multiple entries into the space works across a wide range of users. This includes users bound to wheelchairs, and a wide range of heights and body sizes.