BIOE 477/598DP: Imaging and Therapeutic Probes

Spring Semester, 2019, T/Th 9-10:50 AM, Place: 2101 Everitt

Prof. Dipanjan Pan; Office 1240F Everitt; Phone 217-244-2938; 



Module 1 Imaging and Therapeutic Probes Basics- Lecture Notes

Module 1 (Biological Barriers)- Lecture Notes

Module 1 (Nanomedicine)- Lecture Notes

Module 2 (X-Ray and CT Imaging)- Lecture Notes

Module 2 (CT Contrast Agents and Next Generation CT Techniques)- Lecture Notes

Module 3 (PET Contrast Agents)- Lectures Notes

Module 4 (US Contrast Agents)-Lecture Notes

Module 4 (US Contrast Agents)-Lecture Notes-2

Module 5 (MR Contrast Agents)-Lecture Notes


For Class Room Group Presentation

Team 1: Paper 1 or 2Team 2: Paper 1 or 2Team 3: Paper 1 or 2Team 4: Paper 1 or 2Team 5: Paper 1 or 2Team 6: Paper 1 or 2Team 7: Paper 1 or 2




Class Presentation Schedule

Class Presentation Order:

Team 1, Team 2, Team 3, Team 4, Team 5, Team 6, Team 7 


Course Description: This course will introduce the principles and prerequisites for clinical (MRI, CT, US, PET-SPECT) and pre-clinical (PAT, Optical) imaging modalities and chemical strategies to develop exogenous probes for the early detection of molecular changes responsible for disease pathogenesis  such as cardiovascular, inflammatory, cancer and neurological disorders. We will also discuss in depth the strategies for site-specific delivery of therapeutic agents (chemotherapeutic, thrombolytic, and biologics) with biochemically triggered release mechanisms. The course is designed to teach various aspects of translational medicine from imaging and therapeutic standpoint. Students will be introduced to the fundamentals of various clinical and preclinical imaging modalities, prerequisites for developing probes for these modalities, their application in current clinical practice, and preclinical development in various animal models of cancer, cardiovascular and neurological diseases. We will also explore therapeutic approaches (chemo- and biologics) to these diseases and identify opportunities for personalized preemptive medicine. The course is uniquely tailored for students interested in interdisciplinary translational research with direct clinical focus.

There will be activities to write review chapters as part of the curriculum, which will uniquely give opportunities for students to learn how to write journal manuscripts and publish them in peer-reviewed international journals. Assignments will be given relating to current literature and state of the art in the area of translational medicine.  Laboratory and Imaging facility tours are arranged at the Carle Foundation hospital and Beckman Institute. Homework will be assigned every week, three classroom quizes will be given, final projects will be assigned for small group students, students will submit a report, including a team presentation to the class.

Expected outcomes: Upon completion of this course, students will gain knowledge in:

·  Molecular imaging and drug delivery principles with a pre-emptive clinical medicine focus

·  All aspects of imaging probes/exogenous tracer development.

·  Apply physical principles of imaging modalities and prerequisites for probe development

·  Identify molecular markers of a disease, ligand selection, pre-clinical model.

·  Factors affecting clinical translation of these exploratory techniques (regulatory aspects).

·  Specific examples from successful and seminal clinical studies.

·  Design preclinical experiments with a specific disease in question and corresponding therapy in mind and execute animal experiments in a manner that will optimize their translational potential to early phase human clinical trials.

·  Gain a broad understanding to apprehend and design early-phase clinical studies that resourcefully uses the information obtained from preclinical experiments.

Prerequisites: General chemistry or biochemistry, basic understanding of biology and imaging modalities

Lecture: T/Th 930-1050 AM, Place: Everitt 2101

Office hours: Open door policy; please arrange the meeting by e-mail 

Textbook: All lab materials will be provided via the course website. Optional reference text book: Nanomedicine: A Soft Matter Perspective by Dipanjan Pan (2014 by CRC Press)

Grading for 477: Attendance and participation in class discussion/activity/presentation 20%; Home assignment and quiz 30%; Final project activity/report 25%; Final Exam 25%

Grading for 598: All as 477 and also a mandatory participation in an activity to write a review article

Statement on Academic Integrity:

The University's policy on academic integrity can be found in the Code of Policies and Regulations Applying to All Students under Article One, Part IV. The following policies support and reinforce that policy.

1. Science cannot exist without honesty. We expect all students, as scientists-in-the-making, to hold the highest standards of scientific and academic conduct. Any form of cheating on any graded work in this course is unacceptable, and will be dealt with as outlined below, and in accordance with the University-wide standards in the Code of Policies and Regulations Applying to All Students.

2. We require that all graded work be entirely your own, and that anything you write using the words of other writers be correctly attributed. Some specific points follow:

On assignments, quizzes, and presentations, the answers that you turn in for grading must be your own understanding of the material. Even working within a group, you must contribute to the group's effort and not just have one person do all of the work. Since we cannot monitor you as you complete your work, we have only the appearance of your work from which to judge. If the work that you submit closely resembles that of another student/team too closely, we may conclude that it was not your original work. Failure to adhere to these standards may result in a grade of zero for the entire assignment, for all persons involved.

On assignments, if you use another source to obtain the facts and/or opinions necessary to complete your assignment, you must credit the source (see next point below) and rephrase the information so that your assignment is entirely your own words. A good practice is to read the source until you have a thorough understanding of the material, and then put it away. Write your assignment as if you are explaining the information you learned from reading the source to a classmate, member of your family, or to your teaching assistant. You may wish to look at the source again for clarification, but be certain that you do not use statements taken directly from the text in your assignment. Your entire assignment should be in your own words. Furthermore, paraphrasing does NOT mean replacing key words in a statement with synonyms. For an example of proper paraphrasing of a statement, consult the University's Code of Policies and Regulations Applying to All Students.

Failure to adhere to these standards may result in zero credit for the entire assignment.

On assignments, if you use the ideas and/or opinions from another author or source, you must provide the appropriate citation. That is, you must, using APA format, place a parenthetical reference to the source that provided you the information necessary to complete that portion of the assignment.

Failure to adhere to these standards may result in zero credit for the entire assignment.

On assignments, if you use a statement taken directly from any book or other publication, including the course textbook, you must provide a citation. That is, you must put the text in quotes and, using APA format, place a parenthetical reference to the source at the end of the quote. Direct quotations should be severely limited in your assignment; they should be used ONLY in the following situations:

·       A definition of a term

·       A profound statement made by an expert in the field

Furthermore, any direct quotation should then be restated in your own words in order that your instructor may evaluate your understanding of the material.

Failure to adhere to these standards may result in zero credit for the entire assignment.