Dr. Gregory Underhill
Office: 2112 Everitt Lab
Office Hours: Email Appointment


Principles underlying tissue structure-function relationships.  Engineering methods for manipulating cellular environments.  Quantitative cell and tissue characterization.  Design and clinical translation of cell-based therapies.

Class meets TR 9:30-10:50am in 2310 Everitt Lab.

Course Objectives

Required Textbook


Reading material will be assigned from a combination of book chapters, review articles, and primary research papers.



Two midterms (6th and 12th week of the semester).  Midterms are closed-book exams during the normal lecture period.


Students will organize into groups of approximately 5 students, select a tissue-engineering topic from a list provided, and prepare a proposal that designs an experiment to test a novel tissue engineering approach.  Writing guidelines will be provided at a later date.  Groups will also prepare presentations of their design, to be presented during class.

Homeworks/In-Class Exercises

  1. Approximately 5-6 homework sets based on lectures and assigned reading material.
  2. In class assignments and discussions.

Note: Students may discuss homework problems, but students must complete their own work and write up solutions independently.

In-Class Quizzes

Approximately 10 pop quizzes will be given throughout the semester (roughly 1 per week, excluding project presentation weeks).  These quizzes will be given at the beginning of the lecture period.  The 2 lowest quiz grades will be dropped from the total quiz grade.  A missed quiz due to absence or late attendance will count as one of these dropped quizzes.



Homeworks/In-Class Exercises   24%

In-Class Quizzes  5%

Midterm #1  24%

Midterm #2  24%

Project Presentation  10%

Project Proposal  13%

Letter grade determination:

>97% = A+; >93% = A; >89.5% = A-; >87% B+; >83% = B; >79.5% = B-; >77% = C+; >73% = C; >67% = C-

* Link to student gradebook

Week Of



Homework Due


Introduction: Tissue Engineering and Cell-Based Therapies

Tissue Organization

Reading: paper 1 (read for Tues. 9/4)



Tissue Morphogenesis

Tissue Dynamics

Reading: chapter (read for Tues. 9/11)



Stem Cells and Lineages

Cell Isolation and Culture



Cell-Cell Communication

ECM and Natural Scaffold Materials

Reading: chapter (read for Tues. 9/25)

Homework #1 Due Tuesday 9/18 (in class)

Homework #1 Solutions


Synthetic Biomaterial Scaffolds

Reading: paper (read for Thurs. 9/27)

Scaffold Fabrication & Tailoring

Homework #2 Due Thursday 9/27 (in class)

Homework #2 Solutions


Project Introduction- Review

Midterm #1: Weeks 1-5

Quiz #1 solutions

Quiz #2 solutions

Quiz #3 solutions

Quiz #4 solutions

In-Class Sample Questions & Solutions



Graft Rejection/Material Biocompatibility

Controlled Release/Drug Delivery

Reading: paper (read for Tues. 10/16)




No Lecture

Homework #3 Due Tuesday 10/16 (in class)

Homework #3 Solutions


Cell Migration

Readings and Associated Questions- To be Discussed (Thurs. 10/25)

Cell Mechanics



Microtechnology Tools I

Microtechnology Tools II

Homework #4 Due Tuesday 10/30 (in class)

Homework #4 Solutions


Engineered Disease Models Stem Cell Therapies

Homework #5 (Project Draft Summary)

Due Thursday 11/8 (in class)


Case Study

Midterm #2

Weeks 7-12

Quiz #5 Solutions

Quiz #6 Solutions

Quiz #7 Solutions

Quiz #8 Solutions

Quiz #9 Solutions

Quiz #10 Solutions

Exam- Example Topics to Review

In-Class Sample Questions & Solutions



Thanksgiving Break

Thanksgiving Break


Project Details

Tissue Engineering Ethics

No Lecture

Project Discussion Meetings



Project presentations

Group #1: Microscale Tissue Engineering:  Brittany Amawan,

Avani Patel, Nicole Lima, Lauren Grove, Molly Fay

Group #2: Artificial Cornea: Rodrigo Diaz, Monica Mastalerz,

Stephanie Zimbru, Vincent Cornelius, Tarun Nagarajan

Group #3: Organ-on-a-Chip: Kiran Murphy, Devrina Chidambaram,

Shubhangi Joshi, Yitong Yang, Nikita Mandhan

Group #4: Traumatic Brain Injury: Claire Niewiara,

Ana Rivero Valles, Young Huh, Suyeon Kim, Yujin Lee

Group #5: Epimorphic Limb Regeneration: Krista Habing,

Heather Zelko, Kendall Junger, Monika Kizerwetter, Jackie O'Connor

Project presentations

Group #6: Skeletal Muscle: Rohail Bhurgri, Bri Sarley, 

Mary Figura, Sherri Ho, Joshua Au

Group #7: Bioartificial Kidney: Hannah Meiselman,

Sisi He, Simon Egner, Shannon D'Souza, Manasa Bolla

Group #8: Facial Reconstruction: Kajsa Chen, Jason Wu,

Eamon Bracht, Luke Ang, Justin Tao

Group #9: Spinal Cord: Nathan Apter, Faisal Masood,

Vignesh Alla, Ben David, Craig Soares

Group 10: Engineerd Tumor: Catherin Applegate,

Kelsey Finnamore, Benjamin Liang, Sohil Amin, Bashar Emon




Project presentations

Group 11: Responsive Scaffolds: William Spreadbury,

Monet Worsham, David Zhong, Pranav Ghatraju, Noah Simon

Group 12: Ligament: Jonathan Cruz, Ramon Macias, Jacob Foster,

Kyle Ritchie

Group 13: Heart Patch: Lauren Pritz, Nikita Tummalapalli,

Diana Slater, Alicia Barker, Andrea Daniel

Group 14: Lymphatics: Denzel Ryan Cruz, Amelia Cornman,

James Liu, Carlos Garcia, Tej Patel

Group 15: Cartilage: Luie Siegel, Victor Pastrana-Gomez,

Young Gi Moon, Jared Lund, Reid Jockisch




Exam Week

Written Proposal Due: 

5pm Wednesday 12/19 (1 copy per group, emailed to Prof. Underhill)