Instructor
Dr. Gregory Underhill
gunderhi@illinois.edu
3236 DCL
217-244-2169
Office Hours: Email Appointment
Description
Principles underlying tissue structure-function relationships. Engineering methods for manipulating cellular environments. Quantitative cell and tissue characterization. Design and clinical translation of cell-based therapies.
Class meets TR 9:30-10:50am in 114 Transportation Building.
Course Objectives
- (a) an ability to apply knowledge of mathematics, science, and engineering
- (b) an ability to design and conduct experiments, as well as to analyze and interpret data
- (c) an ability to design a system, component, or process to meet desired needs within realistic constraints such as economic, environmental, social, political, ethical, health and safety, manufacturability, and sustainability
- (d) an ability to function on multidisciplinary teams
- (e) an ability to identify, formulate, and solve engineering problems
- (f) an understanding of professional and ethical responsibility
- (g) an ability to communicate effectively
- (h) the broad education necessary to understand the impact of engineering solutions in a global, economic, environmental, and societal context
- (j) a knowledge of contemporary issues
- (j) a knowledge of contemporary issues
Required Textbook
None.
Reading material will be assigned from a combination of book chapters, review articles, and primary research papers.
Grading
Exams
Two midterms (7th and 13th week of the semester). Midterms are closed-book exams during the normal lecture period.
Project
Students will organize into groups of approximately 6 students, select a tissue-engineering topic from a list provided, and prepare a proposal that designs an experiment to test a novel tissue engineering approach. Writing guidelines will be provided at a later date. Groups will also prepare presentations of their design, to be presented during class.
Homeworks/In-Class Exercises
- Approximately 5-6 homework sets based on lectures and assigned reading material.
- In class assignments and discussions.
Note: Students may discuss homework problems, but students must complete their own work and write up solutions independently.
In-Class Quizzes
Approximately 10 pop quizzes will be given throughout the semester (roughly 1 per week, excluding exam weeks and project presentation weeks). These quizzes will be given at the beginning of the lecture period. The 2 lowest quiz grades will be dropped from the total quiz grade. A missed quiz due to absence or late attendance will count as one of these dropped quizzes.
Grading
Homeworks/In-Class Exercises 24%
In-Class Quizzes 5%
Midterm #1 24%
Midterm #2 24%
Project Presentation 10%
Project Proposal 13%
Letter grade determination:
>97% = A+; >93% = A; >89.5% = A-; >87% B+; >83% = B; >79.5% = B-; >77% = C+; >73% = C; >67% = C-
* Link to student gradebook
|
Week Of |
Tuesday |
Thursday |
Homework Due |
|
8/28 |
Introduction: Tissue Engineering and Cell-Based Therapies |
Tissue Organization Reading: paper 1 (read for Tues. 9/5) |
|
|
9/4 |
Tissue Morphogenesis |
Tissue Dynamics Reading: chapter (read for Tues. 9/12) |
|
|
9/11 |
Stem Cells and Lineages |
Cell Isolation and Culture |
|
|
9/18 |
Cell-Cell Communication |
ECM and Natural Scaffold Materials Reading: chapter (read for Tues. 9/26) |
|
|
9/25 |
Synthetic Biomaterial Scaffolds Reading: paper (read for Thurs. 9/28) |
Scaffold Fabrication & Tailoring |
|
|
10/2 |
Graft Rejection/Material Biocompatibility |
Project Introduction- Review |
|
|
10/9 |
Midterm #1: Weeks 1-6
|
No Lecture |
|
|
10/16 |
Controlled Release/Drug Delivery |
Vascularization |
|
|
10/23 |
Cell Migration Readings and Associated Questions- To be Discussed (Thurs. 10/26) |
Cell Mechanics |
|
| 10/30 |
Microtechnology Tools I |
Microtechnology Tools II |
|
| 11/6 |
Engineered Disease Models |
Stem Cell Therapies |
|
| 11/13 |
Case Study |
Midterm #2 Weeks 8-12
|
|
| 11/20 |
Thanksgiving Break |
Thanksgiving Break |
|
| 11/27 |
Project Details/ Tissue Engineering Ethics |
No Lecture Project Discussion Meetings |
|
| 12/4 |
Project presentations
|
Project presentations
|
|
|
12/11 |
Project presentations
|
|
|
|
Exam Week |
Proposal Due: |
|
|